Recent advances of neurobiological research have highlighted the role of attachment, reward, music and creativity in supporting people who have experienced adversity. Neuropsychotherapy is an integrated form of psychotherapy based on current neurobiological principles and is practiced by psychologists, psychotherapists and medical practitioners internationally. This presentation will offer insights into the principles of neuropsychotherapy and how this knowledge can be transferred to music therapy knowledge and practice. Two case studies within adult mental health and paediatric emergency settings will be shared to demonstrate application of knowledge through the therapeutic process.